Urology Clinical Trials Update: Week 19, 2026

Published May 8, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

Betadine vs Sterile Water for Periurethral Preparation

This Phase 4 trial is exploring whether cleaning the urethra with Betadine or sterile water before inserting a temporary bladder catheter can reduce infection rates and discomfort. For patients who need catheters, this study may identify a simpler or less painful way to prepare the area, potentially making catheter use safer and more comfortable. The trial is currently recruiting 148 participants in the United States.

Effect of Behavioral Sleep Intervention on Lower Urinary Tract Symptoms in Older Women

This study is testing a new approach that combines behavioral sleep therapy with medication to help older women who experience urgency urinary incontinence and frequent nighttime urination. If successful, this method could improve bladder control by addressing sleep problems alongside usual treatments. The trial is recruiting 120 participants across the United States.

High-Frequency Irreversible Electroporation vs Standard of Care for Benign Prostatic Hyperplasia

This trial evaluates a minimally invasive treatment called high-frequency irreversible electroporation, or H-FIRE, for men 50 and older with an enlarged prostate causing urinary symptoms. The goal is to ease symptoms while better preserving sexual function compared to standard surgery. The study plans to enroll 288 men and will follow outcomes for one year.

SeqUential GeMcitabine and MITomycin Treatment for Favorable High-Risk Upper Urinary Tract Urothelial Carcinoma

This Phase 2 trial is testing a chemotherapy combination for patients with high-risk cancer in the upper urinary tract. The treatment aims to control cancer while preserving kidney function and avoiding kidney removal surgery, which is the current standard. The trial is recruiting 28 participants in the United States.

mpMRI Compared to Diagnostic TURBT in Patients With Suspected Muscle-Invasive Bladder Cancer

This pilot study compares the accuracy of multi-parametric MRI to standard surgical biopsy in diagnosing muscle-invasive bladder cancer. If successful, MRI could reduce the need for surgery and provide a less invasive way to diagnose this serious cancer. The study is recruiting 30 patients in the United States.

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