Weekly plain-language updates on clinical trial activity, written for patients and caregivers. TrialsAlert publishes research updates every Friday covering the most notable trials across all monitored conditions.
What are clinical trial research updates?
Clinical trial research updates are weekly summaries of new and updated clinical trials published on ClinicalTrials.gov, the world's largest registry of clinical studies. Each update covers a specific medical specialty or condition, highlighting the most significant trials from the past week. Our AI scores each trial across six dimensions — phase importance, breakthrough potential, patient accessibility, condition prevalence, sponsor credibility, and relevance — then classifies them as breakthrough, notable, or routine. The resulting briefings explain what changed, who is sponsoring the research, what phase it is in, and why it matters for patients, all in plain English without medical jargon. These updates serve patients, caregivers, and support communities who want to stay informed about clinical research without spending hours searching databases themselves.
RSV Vaccine in Transplant Recipients This Phase 3 trial led by the University Health Network in Toronto is testing a new vaccine designed to protect adult lung and stem cell transplant recipients from...
Betadine vs Sterile Water for Periurethral Preparation This Phase 4 trial is exploring whether cleaning the urethra with Betadine or sterile water before inserting a temporary bladder catheter can red...
Safety and Efficacy of GS-100 Gene Therapy in Patients With NGLY1 Deficiency This Phase 3 trial is testing GS-100 gene therapy in children aged 2 to 18 with NGLY1 Deficiency, a rare genetic disorder t...
Study to Evaluate Avacopan in Combination With a Rituximab or Cyclophosphamide-containing Regimen, in Children From 6 Years to < 18 Years of Age With AAV This Phase 3 trial is testing a new treatme...
A Study to Assess the Long-Term Safety and Efficacy of Lebrikizumab (LY3650150) in Participants 6 Months to <18 Years of Age With Moderate-to-Severe Atopic Dermatitis This Phase 3 trial is explorin...
Delaying the Onset of Nearsightedness Until Treatment (DONUT) Clinical Trial This Phase 4 trial is exploring whether using atropine eye drops at night can delay the start of nearsightedness in childre...
Eculizumab in Shiga-toxin Related Hemolytic and Uremic Syndrome Pediatric Patients - ECULISHU This Phase 3 trial studied the drug eculizumab in children suffering from Shiga-toxin related hemolytic ur...
Study on Foster Efficacy Maintenance and Reliever vs Foster Maintenance + Salbutamol Reliever in Asthmatics (MART2) This large Phase 3 trial tested a new way to use asthma inhalers by combining mainte...
May 8, 2026 — 5 trials covered | Women's Health & Gynecology
A Mobile Web App Intervention to Promote Cervical Cancer Screening This study is testing a mobile web app designed to encourage cervical cancer screening among Indigenous women aged 25 to 65 on the Ya...
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations This phase 3 trial is testing new chemotherapy...
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight This Phase 3 study explores two...
May 8, 2026 — 5 trials covered | Digestive Health & Gastroenterology
A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease This Phase 3 trial is testing vedolizumab, a biologic medicine, in children and teenagers with moderate to s...
May 8, 2026 — 5 trials covered | Pediatrics & Child Health
GM-CSF for Reversal of immunopAralysis in pediatriC sEpsis-induced MODS Study This completed study, conducted at multiple sites across the United States, explored a treatment called GM-CSF for childre...
May 8, 2026 — 5 trials covered | Infectious Disease
Oral Islatravir (MK-8591) Once-Monthly as Preexposure Prophylaxis (PrEP) in Men and Transgender Women Who Are at High Risk for HIV-1 Infection (MK-8591-024) This Phase 3 trial examined a new way to pr...
May 8, 2026 — 5 trials covered | Mental Health & Psychiatry
Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury This study from Northwestern University is testing a new digital app designed to support adolescents aged 14 to 18 who engage i...
Tai Chi Intervention for Geriatric Pain Syndrome This study explores a 24-week Tai Chi exercise program aimed at older adults who suffer from chronic pain in multiple areas and have a higher risk of f...
A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease This large Phase 3 trial is studying inclisiran, a newer injection designed to lowe...
Donanemab (LY3002813) Trial in Chinese Participants With Cognitively Unimpaired (Preclinical) Alzheimer's Disease This Phase 3 trial is testing donanemab, an intravenous drug, in Chinese people who do...
May 8, 2026 — 5 trials covered | Cancer & Oncology
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer This phase 3 trial is exploring whether triptorelin can protect the ovaries of adolescent and young adult f...
Safety Study of Viaskin® Peanut Patch in Peanut-Allergic Children 1 Through 3 Years of Age (COMFORT Toddlers) This Phase 3 study is testing a peanut allergy patch for very young children aged 1 to 3 y...
A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain This Phase 3 trial is testing a new once-week...
Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging This Phase 3 trial from the University of Alberta is comparing two imaging method...
Study to Evaluate the Safety and Efficacy of PF-06939926 for the Treatment of Duchenne Muscular Dystrophy This Phase 3 study by Pfizer focused on a gene therapy treatment for boys with Duchenne Muscul...
A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Der...
Extension Study for the Port Delivery System With Ranibizumab (Portal) This Phase 3 study explores a new implantable device that delivers ranibizumab directly into the eye for people with neovascular ...
May 1, 2026 — 5 trials covered | Women's Health & Gynecology
Nonavalent Prophylactic HPV Vaccine (GARDASIL9) After Local Conservative Treatment for Cervical Intra-epithelial Neoplasia This large Phase 3 trial led by Imperial College London is studying the effec...
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin) This Phase 3 trial is testing a new combination pill of BI 690517 with empagliflozin for adults...
May 1, 2026 — 5 trials covered | Digestive Health & Gastroenterology
Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight This Phase 3 trial is exploring a combination treatment of m...
May 1, 2026 — 5 trials covered | Pediatrics & Child Health
An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM This Phase 3 trial is focused on children recovering from complicated severe acute malnutrition ...
A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma This Phase 3 trial is testing tezepelumab, a new biologic medi...