Weekly plain-language updates on clinical trial activity, written for patients and caregivers. TrialsAlert publishes research updates every Friday covering the most notable trials across all monitored conditions.
What are clinical trial research updates?
Clinical trial research updates are weekly summaries of new and updated clinical trials published on ClinicalTrials.gov, the world's largest registry of clinical studies. Each update covers a specific medical specialty or condition, highlighting the most significant trials from the past week. Our AI scores each trial across six dimensions — phase importance, breakthrough potential, patient accessibility, condition prevalence, sponsor credibility, and relevance — then classifies them as breakthrough, notable, or routine. The resulting briefings explain what changed, who is sponsoring the research, what phase it is in, and why it matters for patients, all in plain English without medical jargon. These updates serve patients, caregivers, and support communities who want to stay informed about clinical research without spending hours searching databases themselves.
Mycophenolate Mofetil with Prednisone for Immune Related Hepatitis From Checkpoint Inhibitor Therapy This phase 2 trial from Fox Chase Cancer Center is exploring a new treatment approach for immune-re...
Acetylsalicylic Acid Versus Placebo as an add-on Treatment to Local Non-steroidal Anti-inflammatory Drug for the Management of Thrombotic Episodes in Superficial Venous Malformations in Children Aged ...
A Study of Baricitinib (LY3009104) in Participants From 1 Year to Less Than 18 Years Old With Systemic Juvenile Idiopathic Arthritis (sJIA) This study is testing baricitinib, a new oral medication, fo...
Finerenone for Regression of Albuminuria in Type 2 Diabetes With Chronic Kidney Disease This Phase 4 trial is testing finerenone, an oral medication, for adults in China with type 2 diabetes and chron...
A Multicenter, Open-label Study on the Efficacy and Safety of Tebiovio® (Adalimumab) in Treating Chinese Children With Severe Plaque Psoriasis This study is exploring the safety and effectiveness of T...
Prevention of Urinary Stones With Hydration This completed trial by Duke University studied whether drinking more fluids can help prevent urinary stones from coming back in both adults and children. T...
Opzelura Experience Study This Phase 4 study is testing a topical medication called ruxolitinib for people with atopic dermatitis, a common skin condition that causes itching and redness. The goal is ...
June 26, 2026 — 5 trials covered | Pediatrics & Child Health
Caffeine for Hypoxic Ischemic Encephalopathy This Phase 3 trial is studying whether giving oral caffeine to newborns with hypoxic ischemic encephalopathy (HIE), a serious brain injury caused by lack o...
June 26, 2026 — 5 trials covered | Infectious Disease
A Study in India on the Immune Response and Safety of a Respiratory Syncytial Virus (RSV) Older Adults (OA) Vaccine When Given to Older Adults 60 Years of Age and Above and Adults 50-59 Years of Age a...
June 26, 2026 — 5 trials covered | Digestive Health & Gastroenterology
ENhanced Recovery in CHildren Undergoing Surgery This study focused on children with inflammatory bowel diseases like Crohn's disease and ulcerative colitis who needed gastrointestinal surgery. Resear...
A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma This Phase 3 trial is testing depemokimab, a new antibody treatment, in adults ...
A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes This Phase 3 trial is testing a new oral medication called orforglipron against dulaglutide...
Study to Compare Azacitidine Plus Pevonedistat Versus Azacitidine in Patients With Acute Myeloid Leukemia Not Eligible for Standard Chemotherapy This phase 3 trial is testing a new combination of pevo...
June 26, 2026 — 5 trials covered | Women's Health & Gynecology
Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean This large Phase 3 trial studied tranexamic acid to prevent heavy bleeding after cesarean delivery in women. With 11,000 par...
Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke This large Phase 3 study tested the cholesterol-lowering drug evolocumab in adults at high ri...
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee This Phase 3 study is comparing MACI, a cell therapy, with microfracture surgery for chil...
June 26, 2026 — 5 trials covered | Mental Health & Psychiatry
Smartphones for Opiate Addiction Recovery This Phase 3 trial from NYU Langone Health is testing a smartphone app designed to help people with opioid-use disorder reduce the reuse of illicit opioids. I...
Cannabidiol as add-on Therapy for Children With Refractory Epilepsy (CBD-uN1que), a High-quality Individualized Approach: a Series of N-of-1 Trials This Phase 3 trial is exploring cannabidiol, a compo...
Evaluation of ALLERgen Specific Vaccination of DOG Allergic Patients in Swedish Practice This Phase 4 trial is testing a new allergy vaccine for adults with moderate to severe dog allergy and asthma. ...
Assessing Suzetrigine for Pain Reduction Following Ureteroscopic Surgery This Phase 3 study is exploring suzetrigine, a new non-opioid medication, to help manage pain after ureteroscopic surgery, whic...
Pediatric Patients Aged 1 to 6 Years With APDS This Phase 3 trial is testing leniolisib, an oral medication, in young children with Activated Phosphoinositide 3-Kinase Delta Syndrome (APDS), a rare im...
Trial of Belimumab in Early Lupus This Phase 4 trial is studying belimumab, a treatment designed to modify the immune system, in people with early-stage lupus. The goal is to see if starting belimumab...
Pivotal Study of the Velocity™ pAVF System This study is testing a new, less invasive way to create access for dialysis in adults with kidney failure. The Velocity pAVF System may reduce the need for ...
Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight This Phase 3 trial from Eli Lilly and Company explored the combinati...
Evaluation of the Impact of Oral Ivermectin on Musca Sorbens Flies, Putative Vector of Trachoma This Phase 4 trial is exploring whether oral ivermectin can reduce the population of Musca sorbens flies...
June 19, 2026 — 5 trials covered | Women's Health & Gynecology
The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study This study is exploring a new non-invasive blood test for pregnant individuals to assess fetal genetic condi...
June 19, 2026 — 5 trials covered | Pediatrics & Child Health
GLP-1 Plus Lifestyle for Overall Wellness: Find Your Way Forward This Phase 4 trial is studying the medication semaglutide combined with lifestyle changes to help adolescents with obesity. If the stud...
Tezepelumab Efficacy and Safety in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma This Phase 3 trial studied tezepelumab, a new biologic medicine for adults with ...
A Research Study to Compare a New Weekly Insulin, Insulin Icodec Used With DoseGuide App, and Daily Insulins in People With Type 2 Diabetes Who Have Not Used Insulin Before This Phase 3 study looked a...
June 19, 2026 — 5 trials covered | Digestive Health & Gastroenterology
A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis This Phase 3 trial is exploring the use of filgotinib, an oral medication, for children and teenagers age...