Lung & Respiratory Disease Clinical Trials Update: Week 26, 2026

Published June 26, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma

This Phase 3 trial is testing depemokimab, a new antibody treatment, in adults and adolescents with type 2 asthma who are at risk of flare-ups. If the treatment is effective, it could provide a new option to help reduce asthma attacks and improve lung health for people with this form of asthma. The study is currently recruiting participants in the United States and plans to follow them for up to three years to better understand long-term benefits and safety.

The Options 2 Study

This Phase 4 trial explores the use of nicotine pouches and mini nicotine lozenges as alternatives to cigarettes for smokers who want to quit. These products might offer less harmful ways to reduce cigarette use. The study is recruiting in the United States and involves six in-person visits over several weeks, aiming to find better support options for people trying to stop smoking.

LYT-100 in Post-acute COVID-19 Respiratory Disease

This Phase 2 trial tested LYT-100, an oral medication, in adults with ongoing lung problems after COVID-19 infection. Results are now available and may offer hope for a new treatment that improves lung function and eases breathing difficulties following COVID-19. The study included many sites worldwide, reflecting a broad effort to address long-term respiratory effects of the virus.

Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department

This Phase 4 trial compares a single intramuscular steroid injection to a five-day oral steroid course for adults experiencing asthma attacks in the emergency department. If the injection is as effective, it could simplify treatment and reduce the need for longer medication courses. The study is recruiting at one site in the United States and plans to enroll 182 participants to determine the best approach.

Aligning With Schools To Help Manage Asthma (Project ASTHMA)

This completed study tested a school-based asthma care program that provided daily preventive medication to children with asthma, especially in communities facing health disparities. The program aimed to improve asthma control, reduce emergency room visits, and decrease missed school days. Results are available and may help guide better asthma management for children in school settings.

TrialsAlert subscribers received the full impact-classified briefing and doctor-ready report this week. Get weekly briefings at trialsalert.com.