Lung & Respiratory Disease Clinical Trials Update: Week 23, 2026

Published June 5, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children

This Phase 4 trial from the University of Minnesota is testing progesterone capsules to help women avoid returning to smoking after giving birth. If successful, this hormonal approach could protect both mothers and their babies by reducing the risk of smoking relapse and secondhand smoke exposure. The study is active but not currently recruiting and is taking place at a single site in the United States.

Metformin Treatment for Children With Obesity-associated Asthma

This Phase 3 trial in Qatar is studying whether metformin can improve asthma control and overall health in children who have asthma linked to obesity. Metformin is usually used for diabetes, but here it may help reduce asthma symptoms while also addressing weight-related issues. Results are expected after 26 weeks of treatment, offering hope for a new way to manage this specific type of childhood asthma.

Nuevo Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples With Implications for Alzheimer's Disease Risk

The University of Utah is conducting a Phase 2 trial that adapts a couples-based program to help Latino adults with sleep apnea use their positive airway pressure (PAP) machines more consistently. Improving sleep health together may also support memory and reduce Alzheimer’s risk. This study is recruiting in the United States and plans to enroll 80 participants, focusing on culturally relevant support to enhance treatment success.

Oral Bacterial Extract for the Prevention of Wheezing Lower Respiratory Tract Illness

This completed Phase 2 trial from the University of Arizona tested an oral bacterial extract to prevent wheezing episodes in infants who are at high risk for asthma. With over 800 participants, the results could guide future ways to reduce early respiratory problems in young children, potentially delaying or lessening asthma development. The findings may help inform new preventive treatments for families with at-risk infants.

Efficacy of Ultraviolet Germicidal Irradiation Devices to Reduce Respiratory Infections in Nursing Homes: Cluster Randomized Crossover Trial

This trial in France is evaluating ultraviolet germicidal irradiation devices to lower severe respiratory infections among elderly nursing home residents. By reducing infections without relying on medication, this approach might create safer living environments for vulnerable seniors. Results are expected by mid-2026 and could influence infection control practices in care facilities worldwide.

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