Lung & Respiratory Disease Clinical Trials Update: Week 15, 2026

Published April 10, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert

Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Sevoflurane Anesthesia

This Phase 4 trial from Sun Yat-sen University is testing whether inhaled penehyclidine can prevent breathing problems during anesthesia in children who are at risk. The study focuses on kids undergoing minor elective surgeries in China and aims to reduce complications that may happen while they are under sevoflurane anesthesia. If successful, this treatment could make surgery safer by lowering the chance of respiratory issues in vulnerable children.

Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

GlaxoSmithKline is conducting a Phase 3 trial to see if depemokimab, a biologic medication, can help adults with moderate to severe COPD who also have type 2 inflammation. This study includes participants from multiple countries and focuses on those with symptoms that are not well controlled. If proven effective, depemokimab could offer a new add-on treatment to better manage COPD symptoms and reduce flare-ups, potentially improving daily life for many patients.

Cigarillo Warnings Image Sorting Study

Researchers at Boston University completed an online study with 764 young adult cigarillo users in the United States. The study tested different warning labels with images on cigarillo packages to see which messages might encourage users to quit smoking. The results could help shape better public health warnings, making it easier for cigarillo smokers to consider quitting and improve their lung health.

Asthma Ctrl SMART Trial

This trial from the Children’s Hospital Medical Center in Cincinnati is exploring the use of a smartphone app to help teenagers with asthma take their medications more regularly. By improving inhaler use through digital tracking and reminders, the app aims to help young patients better control their asthma symptoms. The study is recruiting in the United States and could provide helpful tools for managing asthma in adolescents.

A Text Messaging Trial to Test Vaping Health Messages Optimized to Young Adults' Vaping Status

The University of Hawaii is running a study that sends tailored text messages to young adults based on their vaping habits. Participants receive messages three times a week for six months, designed to influence their vaping behavior. If this approach works, text messaging could become an easy and flexible way to help young people reduce or avoid vaping, supporting healthier lungs.

TrialsAlert subscribers received the full impact-classified briefing and doctor-ready report this week. Get weekly briefings at trialsalert.com.