Mental Health & Psychiatry Clinical Trials Update: Week 15, 2026

Published April 10, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert

Testing the Use of VA Peer Specialists to Prevent Veteran Suicide

This Phase 3 trial is studying whether a peer specialist support program can help prevent suicide in Veterans living with serious mental illness. If this approach proves effective, it may offer Veterans a new way to find hope and safety through support from peers who understand their experiences. The study plans to enroll 306 Veterans across the United States, and its results could shape how care is delivered in VA facilities nationwide.

Psilocybin-Assisted Therapy in Treatment-Resistant Depression

This Phase 3 trial is exploring psilocybin-assisted therapy as a treatment for adults whose depression has not improved with other methods. By following participants for a year after treatment, the study aims to understand if this therapy can provide lasting relief for people with treatment-resistant depression. The trial is currently recruiting in the United States and may offer a new hope for those struggling with persistent depressive symptoms.

Long-term Antipsychotic Pediatric Safety Trial

This trial focuses on the long-term effects of antipsychotic medications on weight gain in children aged 3 to under 18 years. Since children may experience more weight gain from these drugs than adults, understanding these effects is important for managing their overall health. The study involves yearly visits and monthly remote assessments at multiple locations in the United States to monitor changes over time.

PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study

This study tests a mobile phone-supported program designed to help people who inject drugs access and stick to HIV prevention and opioid use disorder treatments. By providing peer coaching and rapid medication starts, the program aims to make these important health services easier to reach and use. The trial is recruiting in the United States and could improve health outcomes for people at high risk of HIV and opioid-related harms.

Empowering Youth With School Discipline Referrals as Peer Coaches

This study is investigating a behavioral program that trains middle-school youth with school discipline referrals to become peer coaches. The goal is to empower these young people to encourage positive behaviors among their peers and reduce disruptions in school. Recruiting 150 participants in the United States, this research hopes to improve school experiences and promote prosocial behavior among youth.

TrialsAlert subscribers received the full impact-classified briefing and doctor-ready report this week. Get weekly briefings at trialsalert.com.