Mental Health & Psychiatry Clinical Trials Update: Week 14, 2026

Published April 3, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert

Esketamine Versus Crisis Response Planning Versus Optimized Treatment as Usual for Suicide Prevention: A Pragmatic Controlled Trial in Two Brazilian Cities

This Phase 4 trial led by the University of Sao Paulo is testing two approaches to prevent suicide in people aged 14 and older. One treatment uses esketamine infusions, while the other focuses on crisis response planning, a structured way to manage suicidal thoughts. By following participants for a year, the study aims to find faster and more effective methods to reduce suicide risk and improve mental health care in Brazil.

A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism

This Phase 3 trial sponsored by Bristol-Myers Squibb is evaluating a new combination treatment called KarXT plus KarX-EC. It targets irritability symptoms in children and adolescents with autism spectrum disorder. If successful, this study could provide families with a new option to help manage challenging behaviors and improve daily life for young people with autism.

Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability

Conducted by the Centre for Addiction and Mental Health, this Phase 4 trial is testing whether metformin can help reduce weight gain caused by antipsychotic medications in adults with intellectual and developmental disabilities. Weight gain is a common side effect that can increase health risks. This study could offer a new way to support physical health in this underserved population.

Efficacy of Trigeminal Nerve Stimulation for ADHD

Researchers at the University of California, Los Angeles are studying a non-invasive nerve stimulation treatment for children ages 7 to 12 with attention-deficit hyperactivity disorder. This treatment aims to be low risk and easy to use. If effective, it might become a helpful alternative for managing ADHD symptoms without medication.

Cognitive Training for Student Sleep and Wellness

Carnegie Mellon University is investigating two digital programs designed to reduce stress and improve sleep among first-year college students. Better sleep and mental well-being can support academic success and overall health. This study could provide accessible tools for young adults adjusting to college life.

TrialsAlert subscribers received the full impact-classified briefing and doctor-ready report this week. Get weekly briefings at trialsalert.com.