Pediatrics & Child Health Clinical Trials Update: Week 40, 2026

Published October 2, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Sinusitis)

This study is looking at whether antibiotics or a placebo work better in easing symptoms for children with acute sinusitis. By tracking symptoms daily, parents can help doctors understand when antibiotics are truly needed. This could reduce unnecessary use of antibiotics and help children recover more safely and effectively from sinus and ear infections.

Treatment of Neonatal Encephalopathy With Oral Sildenafil Suspension to Repair Brain Injury Secondary to Birth Asphyxia

This trial is testing an oral medication called sildenafil to help newborns who have brain injury due to lack of oxygen at birth. If the treatment works, it may help improve brain healing and later development in these babies. The study is enrolling infants in the US and Canada and hopes to offer a new way to support brain recovery early on.

Project AFECT (Autism Family Empowerment Coaching and Training Program)

This study focuses on supporting families with young children newly diagnosed with autism. It offers coaching to parents to reduce stress, boost confidence, and improve access to early services that help children learn language and other skills. The results will help design better support programs that meet the needs of diverse families.

NIV-NAVA in Infants With Severe Bronchiolitis, a Pilot Multicenter Randomized Controlled Trial

This pilot study tests a new non-invasive breathing support method called NIV-NAVA for infants with serious lung infections. The goal is to help babies breathe better without needing tubes placed in the windpipe, which can be uncomfortable and risky. The trial is taking place in several Canadian hospitals and may improve care for infants with severe bronchiolitis.

The Puerto Rico Asthma Integrated Response Program ("PR-AIR")

This study is trying a new program to help children with asthma in Puerto Rico better control their symptoms and avoid hospital visits. It combines virtual and in-person support to make care easier to get and more effective. The program aims to reduce asthma problems in a community that faces higher asthma risks and challenges.

TrialsAlert subscribers received the full impact-classified briefing and doctor-ready report this week. Get weekly briefings at trialsalert.com.