Orthopedics & Musculoskeletal Clinical Trials Update: Week 45, 2026

Published November 6, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)

This Phase 3 study is exploring whether the drug berobenatide can help adults with knee osteoarthritis who are also overweight or obese. The goal is to see if berobenatide can reduce knee pain and improve physical function better than a placebo. This trial, recruiting in the US and Canada, may offer a new option for managing knee pain over about one year of treatment.

Effect of Ondansetron on the Incidence of Spinal Anaesthesia-Induced Hypotension in Elderly Patients Undergoing Fracture Hip Surgery

This Phase 4 trial is testing if giving ondansetron through an IV can prevent low blood pressure caused by spinal anesthesia in older adults having hip fracture surgery. Low blood pressure during surgery can lead to complications, so if ondansetron works, it could make surgery safer for elderly patients. The study is currently recruiting in Egypt and plans to enroll 142 participants.

No Reduction Compared to Closed Reduction for Distal Radius Fractures in Patients Over 65 or Older

This trial is investigating whether simply casting wrist fractures without first performing a closed reduction (a procedure to realign the bone) is as effective for patients aged 65 and older. Avoiding the reduction step might reduce discomfort and simplify treatment without affecting healing. The study is recruiting in several Nordic countries and will follow patients for up to 12 months.

Integrating Sport-Specific Comprehensive Training to Upscale Performance in Women and Girls

This study aims to improve sport performance and reduce injury risk for female athletes aged 11 to 26 by combining physical, sensorimotor, and mental training tailored to their needs. Female athletes often face different challenges than males, and this program seeks to address those specific needs. The trial plans to enroll 250 participants but is not yet recruiting.

The Effectiveness of a Fall Prevention Program

This study looks at whether removing hazards in the homes of older adults who have already fallen can help prevent future falls. Falls can cause serious injuries, so making homes safer may reduce these risks. The trial enrolled 129 participants in the United States and will provide information on how to better protect seniors from falls.

TrialsAlert subscribers received the full impact-classified briefing and doctor-ready report this week. Get weekly briefings at trialsalert.com.