Orthopedics & Musculoskeletal Clinical Trials Update: Week 44, 2026

Published October 30, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

Suzetrigine (Journavx) as Multimodal Therapy for Pain Management in Adults Undergoing Surgery for Hip Fracture

This study is exploring suzetrigine, a new oral medication, as an addition to standard pain relief for adults having surgery for hip fractures. The goal is to provide effective pain control while reducing the amount of opioids needed after surgery. For patients, this could mean better pain management with fewer opioid-related side effects and risks during recovery.

Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee

This upcoming trial aims to test a new approach to pain management that reduces opioid use for people undergoing knee replacement surgery. By improving how pain is managed after surgery, the study hopes to help patients recover more safely and with less reliance on opioid medications. The trial plans to include 170 participants once recruitment begins.

Monitored Anesthesia Care and Soft Tissue Infiltration With Local Anesthesia Feasibility Trial

This study is investigating the use of monitored anesthesia care combined with local anesthesia during hip fracture surgery for older adults. If effective, this approach could reduce the chances of postoperative confusion and delirium, common issues in elderly patients after surgery. The trial is enrolling patients at multiple centers and includes those with or without cognitive impairments.

Craniomaxillofacial and Upper Extremity Allotransplantation

This trial is testing a combined transplant surgery for patients with severe facial and upper limb injuries who have not had success with standard reconstructive methods. The procedure aims to restore both appearance and function in complex trauma cases. The study is recruiting up to 10 patients in the United States and offers hope for those with devastating injuries.

Village Doctor-Delivered Fall Prevention Program for Older Adults in Rural Chongqing

This completed trial evaluated a fall prevention program delivered by village doctors to older adults at high risk of falls in rural China. The program’s success could provide a practical and locally accessible way to reduce falls and related injuries through community healthcare providers. Results from 320 participants followed over 12 months may influence fall prevention strategies in similar rural settings.

TrialsAlert subscribers received the full impact-classified briefing and doctor-ready report this week. Get weekly briefings at trialsalert.com.