Orthopedics & Musculoskeletal Clinical Trials Update: Week 26, 2026

Published June 26, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee

This Phase 3 study is comparing MACI, a cell therapy, with microfracture surgery for children and teenagers who have painful cartilage damage in the knee. If the results show MACI works better, it could offer young patients a new option that may reduce pain and improve knee function more effectively than current surgeries. The trial is recruiting 45 participants in the United States, and results are expected after enrollment.

IRONCARE: Iron Treatment in Older Patients With Hip Fractures

This Phase 4 trial is testing iron treatments given by vein or by mouth to older adults who have had hip fractures and anemia. The goal is to see if improving iron levels can help reduce fatigue and memory problems after surgery, which are common challenges in recovery. The study is currently recruiting 528 patients across five hospitals in Denmark.

A Study to Evaluate the Efficacy and Safety of IN-207907 Injection in Elderly Patients With Sarcopenia

This Phase 2 trial will test a new drug, IN-207907, given by injection to elderly patients with sarcopenia, a condition that causes loss of muscle strength and mass. If successful, this treatment could help older adults improve their muscle strength and overall physical abilities. The study plans to enroll 100 participants but is not yet recruiting.

Evaluation of a Structured Hospital-Community Care Follow-up Based on Perceived Quality of Care After Surgery, Aimed at Reducing Persistent Opioid Use in Primary Care: a Pragmatic Randomized Controlled Trial

This trial is testing whether a structured follow-up program involving both hospital and community care can help patients stop using opioids after surgery. The program uses feedback directly from patients to guide care and aims to prevent long-term opioid use, which can be a concern after operations. The study will enroll 772 patients and is not yet recruiting.

Comparison of Norepinephrine Versus Phenylephrine Infusion for Prevention of Post-spinal Hypotension

This study compares two medicine infusions used during spinal anesthesia to prevent low blood pressure in elderly patients undergoing hip surgery. Low blood pressure during surgery can cause complications, so finding the safest and most effective option could improve surgical outcomes for older adults. The trial is recruiting patients aged 60 and above in Egypt.

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