Orthopedics & Musculoskeletal Clinical Trials Update: Week 25, 2026

Published June 19, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Fracture Surgery

This study is exploring a new nerve block technique that uses liposomal bupivacaine to provide longer-lasting pain relief for older adults after hip fracture surgery. By potentially reducing the need for opioid painkillers, this approach may help improve recovery quality and comfort during the critical postoperative period. The trial is currently recruiting patients in China and aims to enroll 148 participants.

Alignment Techniques in TKA RCT

This trial compares two surgical alignment methods during total knee replacement in patients with knee osteoarthritis who are also overweight or obese. It investigates whether using technology-assisted surgery can lead to better knee function and faster recovery compared to traditional manual techniques. Although it is not yet recruiting, the study plans to enroll 80 patients and could influence surgical practices in knee replacement.

Contribution of the MEOPA in the Physiotherapy Care of Painful Articular Steepness Among Elderly

This completed study in France evaluated the use of MEOPA gas to reduce pain during physiotherapy for elderly patients experiencing joint stiffness. If MEOPA proves effective, it might provide a safer way to manage pain with fewer side effects during rehabilitation, helping older adults regain joint movement more comfortably. The trial involved a small group of participants and focused on improving care options in this population.

Tegileridine for Postoperative Pain After Adolescent Scoliosis Surgery

This trial is testing a new pain medicine called Tegileridine for teenagers recovering from scoliosis surgery. By offering an alternative to morphine, it aims to provide effective pain relief with potentially fewer side effects. The study uses a patient-controlled pump system and is recruiting 171 participants in China, focusing on improving pain management after surgery for adolescents.

Stepping-Up: Partnering With the Community to Prevent Early Mobility Decline

This study is examining a combined walking and yoga program designed to help older adults who are beginning to experience mobility decline. The goal is to slow down or prevent worsening mobility problems and reduce the risk of falls through accessible, non-medication interventions. The program is active in Canada and enrolling 249 participants, offering a community-based approach to maintaining independence.

TrialsAlert subscribers received the full impact-classified briefing and doctor-ready report this week. Get weekly briefings at trialsalert.com.