Orthopedics & Musculoskeletal Clinical Trials Update: Week 24, 2026

Published June 12, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

Bone, Exercise, Alendronate, and Caloric Restriction

This Phase 4 study led by Wake Forest University Health Sciences is investigating ways to protect bone health in older adults who are losing weight. The trial tests treatments including the medication alendronate combined with exercise to reduce bone loss, which often happens during weight loss and can increase fracture risk. Participants in the United States are followed for up to two years with multiple check-ins, aiming to find effective strategies to keep bones strong while managing weight.

Clinical Study to Predict the Risk of Bone Fractures With the POROUS Ultrasound Device

Researchers in Europe are testing a new ultrasound device designed to better predict the risk of bone fractures in middle-aged and older adults with conditions like osteoporosis or osteopenia. This device could offer earlier and more accurate detection of fracture risk than current methods, allowing for timely care to protect bone health. The study is recruiting adults aged 55 and older across several European countries and will follow participants for three years.

Effects of a Powered Lower-Limb Exoskeleton on Walking Performance in Older Adults

This upcoming trial from Hunan Normal University will test a powered lower-limb exoskeleton to help improve walking ability in older adults aged 65 to 75. The device aims to enhance mobility and reduce difficulties with walking, which can contribute to better independence and quality of life. Although the study is not yet recruiting, it represents a promising approach to support physical function as people age.

Remote Digital Health Intervention to Improve Balance and Reduce Fall Risk

Posit Science Corporation completed a study on a computerized cognitive training program aimed at improving balance and lowering fall risk in older adults. With 32 participants in the United States, the program offers a non-drug option to help maintain independence by reducing the chance of falls. Results from this trial provide insights into how digital tools can support safer mobility for seniors.

Personalized Rehabilitation Program for Elderly Patients That Fall

In France, Lille Catholic University evaluated a personalized home-based rehabilitation program for elderly individuals who have experienced a fall. The program focuses on exercises and home adjustments to reduce fear of falling and improve safety. This approach aims to help older adults regain confidence and maintain independence after a fall.

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