Orthopedics & Musculoskeletal Clinical Trials Update: Week 18, 2026

Published May 1, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

GLP-1R Actions on Muscle and the Skeleton

This Phase 4 trial is studying the effects of tirzepatide combined with diet and exercise for people who have both obesity and musculoskeletal problems. The goal is to find out how this treatment influences muscle and bone health while losing weight, which could lead to better ways to manage these conditions. The study is currently recruiting participants in the United States and includes lifestyle changes alongside the medication.

Supracondylar Humerus Fracture (SCHF) Post-Op Study Between Opioid and Non-Opioid Pain Management

This completed study compared opioid and non-opioid pain treatments for children recovering from surgery for a broken upper arm bone near the elbow. Results from 137 children at a single US site are now available. The findings may help reduce opioid use while still providing effective pain relief for kids after this common fracture surgery.

Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans

This active trial is testing a nutritional supplement called nicotinamide riboside to see if it can improve muscle strength and function in older veterans with muscle loss related to aging. If successful, this could offer a new way to help maintain muscle health and physical abilities as people get older. The study includes 74 participants across the United States.

Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery

This Phase 2 trial is investigating whether the drug aprepitant can reduce nausea and vomiting after spinal surgery in children and teens with scoliosis. Preventing these uncomfortable symptoms could make recovery easier for young patients. The study is recruiting in Canada and aims to enroll 100 participants.

Evaluation of a Digital Person-Centered Rehabilitation Program Targeting Physical Activity in Spinal Stenosis Surgery (Get Back)

This trial is testing a digital rehabilitation program called Get Back designed to help people recovering from lumbar spinal stenosis surgery increase their physical activity. The program offers a personalized and easy-to-use approach to support recovery. The study is recruiting in Sweden and plans to include 252 patients from multiple clinics.

TrialsAlert subscribers received the full impact-classified briefing and doctor-ready report this week. Get weekly briefings at trialsalert.com.