Orthopedics & Musculoskeletal Clinical Trials Update: Week 17, 2026

Published April 24, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

Feasibility of Home-based tES for Older Adults at Risk of Falling

This ongoing study by Hebrew SeniorLife explores a new brain stimulation treatment that older adults can use at home to improve their balance and reduce the chance of falling. The treatment involves caregivers helping with the therapy, making it easier for seniors to maintain their mobility without frequent visits to clinics. If successful, this approach could support many older adults in staying independent and safer in their daily lives.

Phase II Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis

Researchers at Union Hospital in China are testing umbilical cord stem cells to treat knee osteoarthritis, a common cause of pain and reduced movement. This trial aims to not only relieve pain but also help repair damaged knee cartilage. Results from this study could lead to new treatments that improve joint health and quality of life for people with mild to moderate osteoarthritis.

Peiyuan Guben Tongluo Ointment for Elderly Sarcopenia

This study in China is examining a topical ointment combined with nutrition and exercise to help older adults who experience sarcopenia, a condition involving loss of muscle strength and mass. The treatment could offer a new way to improve muscle health and physical function in the elderly. Participants are expected to see results after 12 weeks, which will show whether this combined approach is effective.

Multifaceted Intervention Using Telehealth to Reduce the Risk of Falls and Fractures in Older Men

Completed at McGill University in Canada, this pilot study tested a virtual program combining exercise and nutrition advice to help older men with osteoporosis. The goal was to reduce falls and broken bones by improving mobility and bone health through telehealth sessions. Findings from this small study will guide larger efforts to better support men at risk for fractures.

Aging Resilience Through Microbiota Optimization and Regulation

This Phase 1 trial in Chile is looking at whether capsules containing transplanted gut bacteria can improve muscle strength, brain function, and metabolism in older adults with sarcopenia. The treatment could provide a new way to maintain overall health and resilience as people age. Researchers plan to enroll 80 participants to understand the potential benefits of this innovative approach.

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