Eye Disease & Ophthalmology Clinical Trials Update: Week 16, 2026

Published April 17, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert

Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

This Phase 3 trial is testing a new treatment called 4D-150 for adults with neovascular age-related macular degeneration, a major cause of vision loss. The treatment involves a single injection into the eye, which may reduce the need for frequent injections compared to current options. If successful, this could mean fewer clinic visits and less discomfort for patients managing this chronic condition.

Post Marketing Study to Evaluate the Safety and Effectiveness of Brolucizumab in Patients With Diabetic Macular Edema

This Phase 4 study is evaluating the real-world safety and effectiveness of brolucizumab injections for diabetic macular edema, a common complication of diabetes that affects vision. Conducted in India with 66 participants, the study aims to provide more information about how well this treatment works outside of controlled clinical trials. Results from this research will help doctors and patients understand the benefits and risks of brolucizumab in everyday care.

Safety and Efficacy of T10430 Eye Drops in Controlling Paediatric Myopia Progression

This Phase 2 trial is investigating whether T10430 eye drops can safely slow or stop nearsightedness from worsening in children. Myopia that progresses quickly during childhood can lead to serious eye problems later in life. By recruiting children from several countries, this study hopes to find a treatment that can protect young eyes and improve long-term vision health.

Clinical Efficacy of Implementing an AI-SaMD for Funduscopy Analysis in Patients With Diabetes Mellitus

This study is evaluating an artificial intelligence software designed to assist in detecting diabetic retinopathy from eye images. Early detection of this diabetes-related eye disease is crucial for preventing vision loss. Conducted in South Korea with 340 participants, the trial could lead to faster and more accurate screening in clinics, benefiting many patients living with diabetes.

RESTORE: Comparing Two Approaches to Repeat TT Surgery Performed by Integrated Eye Care Workers (IECWs)

This trial compares two types of repeat eyelid surgeries for trichiasis, a painful eye condition caused by trachoma that can lead to blindness. With plans to enroll 1,000 participants in Tanzania and the United States, the study aims to improve surgical outcomes and help patients maintain better vision and quality of life. The findings could influence how repeat surgeries are performed worldwide.

TrialsAlert subscribers received the full impact-classified briefing and doctor-ready report this week. Get weekly briefings at trialsalert.com.