Neurology & Brain Disorders Clinical Trials Update: Week 32, 2026

Published August 7, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

Outcomes After Planned Discontinuation of AntiSeizure Medication

This Phase 4 trial from the University of Michigan is exploring what happens when people with epilepsy who have been seizure-free stop taking their antiseizure medications. The study aims to find out if stopping medication can reduce side effects without causing seizures to return. For patients, this could mean a path toward fewer medication-related issues while maintaining seizure control, potentially improving quality of life.

The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

Conducted by the California Pacific Medical Center Research Institute, this study is testing whether treating obstructive sleep apnea (OSA) in older adults can improve memory and reduce markers linked to Alzheimer's disease. If effective, better management of sleep apnea might become an important way to protect brain health and slow cognitive decline. This could offer new hope for older adults experiencing memory problems alongside sleep issues.

Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC)

Boston Children's Hospital is running this observational study to learn more about how autism and intellectual disability develop in children with tuberous sclerosis complex. By studying developmental and biological markers, researchers hope to improve diagnosis and guide future treatments. Families affected by these conditions may benefit from better understanding and tailored care options down the line.

Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome

This study led by Ann & Robert H Lurie Children's Hospital of Chicago compares two treatment approaches for children with Lennox-Gastaut syndrome: palliative surgery or adding more anti-seizure medications. The goal is to determine which option better reduces seizures and supports development. Results could help families and doctors choose the most effective treatment path for these complex cases.

Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (The Exergames Telerehabilitation Study)

The University of Minnesota is testing a home-based program combining aerobic exercise and cognitive training aimed at older adults at risk for Alzheimer's disease. This non-drug approach hopes to delay memory loss and improve daily functioning using accessible activities. If successful, it could offer an easy-to-use way for people to support brain health from home.

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