Infectious Disease Clinical Trials Update: Week 14, 2026

Published April 3, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert

Pre-Exposure Prophylaxis Study of Lenacapavir and Emtricitabine/Tenofovir Alafenamide in Adolescent Girls and Young Women at Risk of HIV Infection

This Phase 3 study explores two HIV prevention medications, lenacapavir and emtricitabine/tenofovir alafenamide, in adolescent girls and young women. The goal is to find an easier way to protect against HIV with less frequent dosing, which could improve adherence and effectiveness. Conducted in countries including South Africa and Uganda, the study is active but not recruiting and has already shared results.

Evaluate the Safety and Efficacy of Nirsevimab in Healthy Preterm and Term Infants in China

This Phase 3 trial evaluates Nirsevimab, a monoclonal antibody designed to prevent serious lung infections caused by respiratory syncytial virus (RSV) in infants. It includes 800 healthy preterm and term infants across 30 sites in China. If successful, Nirsevimab might offer an important new way to protect young children from severe respiratory illness.

Clinical Trial of the S. Flexneri-S. Sonnei Bivalent Conjugate Vaccine

This Phase 3 study tests a vaccine aimed at preventing Shigella infections, which cause diarrhea and dysentery in young children. The trial involves 8000 infants and children aged 6 months to 5 years in Bangladesh. A successful vaccine could reduce illness and improve child health in areas where Shigella is common.

A Phase III Study of Deuremidevir Hydrobromide for the Treatment of RSV Infection in Infants and Young Children

This trial is testing Deuremidevir Hydrobromide, an oral antiviral drug for infants and young children with respiratory syncytial virus infection. Recruiting children aged 1 to 36 months in China, the study aims to find a simple treatment that might shorten illness and ease symptoms. This could be a helpful option for families dealing with RSV.

A Pragmatic Assessment of Influenza Vaccine Effectiveness in the DoD

This Phase 4 trial compares different flu vaccines to find out which provides the best protection in adults. Conducted at multiple US locations, the study has results available from previous flu seasons. These findings may guide better flu prevention strategies to keep more people healthy during flu season.

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