Immunology Clinical Trials Update: Week 16, 2026

Published April 17, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert

Improving Vaccine Protection for Older Adults

A Phase 2 trial led by Singapore General Hospital is exploring whether the AS01 adjuvant can boost immune responses in adults aged 21 to 59. This study focuses on healthy adults and aims to find ways to strengthen vaccine protection, which is especially important as people age and their immune systems naturally weaken. If successful, this approach could lead to vaccines that offer better defense against infections for older adults.

Basophil Activation Test (BAT) Sensitivity in Child Food Allergy

This completed Phase 4 study by University Hospital, Rouen, evaluated a new blood test called the Basophil Activation Test for children with egg or peanut allergies. The goal was to see if this test can accurately measure allergy sensitivity, which might reduce the need for traditional food challenge tests that carry more risk. With 140 children participating, the results could help families manage food allergies more safely and comfortably.

Impact of Thymectomy on Immunity in Infants After Cardiac Surgery

Nantes University Hospital is conducting a study on how removing part or all of the thymus gland during heart surgery affects immune function in infants. Since the thymus plays a key role in immune system development, preserving part of it may help reduce immune problems and infections after surgery. This ongoing trial involves blood tests during surgery and one year later to better understand these effects.

Epigenetic Effects in Children With Cow's Milk Allergy Treated With Different Formulas

Federico II University completed a study in Italy investigating how different hypoallergenic formulas affect children with cow’s milk allergy. The focus was on epigenetic changes, which influence how genes related to the immune system are expressed. Understanding these effects could lead to better dietary options that help children develop tolerance and manage their allergy more effectively.

Prevention av Autoimmunitet Med Laktobaciller

This Swedish trial from Lund University tested a probiotic treatment in children who have autoantibodies linked to celiac disease, type 1 diabetes, and thyroid issues. By potentially regulating the autoimmune process, the treatment may delay or prevent these diseases from developing. The study is completed, and results are pending, offering hope for new ways to support children at risk of autoimmune conditions.

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