Women's Health & Gynecology Clinical Trials Update: Week 14, 2026

Published April 3, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert

Nonavalent Prophylactic HPV Vaccine (GARDASIL9) After Local Conservative Treatment for Cervical Intra-epithelial Neoplasia

This Phase 3 trial studied Gardasil 9, an HPV vaccine, in women who had treatment for high grade cervical intra-epithelial neoplasia. The goal was to see if the vaccine could lower the risk of getting another HPV infection and prevent cervical lesions from worsening. With over 1000 women involved across several countries, the results could offer a new way to protect women after treatment of precancerous cervical changes.

Different Medications to Induce Labor

This Phase 3 study compared two medications, misoprostol and pitocin, for inducing labor in pregnant women with a body mass index over 30. Since obesity can affect labor, the trial aimed to find which medicine works better and is safer for this group. The findings may help doctors choose the best method to safely support labor and delivery in women with higher BMI.

Mirena for the Treatment of Nonatypical Endometrial Hyperplasia for 6 Months

This Phase 3 trial is testing the Mirena device, which releases hormones, in women with nonatypical endometrial hyperplasia, a condition where the uterine lining is too thick but not cancerous. The study hopes to find a safe and effective treatment to restore a normal uterine lining. It is actively recruiting women in several countries and results are expected after six months of use.

Self-Collection of the Pap Smear as Agency: A Novel Way to Improve Refractory Low Cervical Cancer Screening Rates in Rural Alabama

This study is exploring whether women can collect their own sample for a Pap smear instead of having a clinician do it. The aim is to make cervical cancer screening easier, especially for women living in rural areas with low screening rates. If successful, this approach could increase screening and early detection in communities with limited access to healthcare.

Comparison Between Letrozole and Mifepristone in Medical Termination of First Trimester Miscarriages

This Phase 3 trial compared two medication combinations to medically end first trimester miscarriages. Conducted in India with 120 participants, the study looked for options that might be more effective or reduce the need for surgical procedures. The results are still pending and could offer women additional choices for managing early pregnancy loss.

TrialsAlert subscribers received the full impact-classified briefing and doctor-ready report this week. Get weekly briefings at trialsalert.com.