Women's Health & Gynecology Clinical Trials Update: Week 13, 2026

Published March 29, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

A Trial to Establish Non-inferiority of Immunogenicity of a Single-dose of CERVAVAC® Quadrivalent HPV Vaccine Compared to the Gardasil® Quadrivalent Vaccine Among Girls and Boys Aged 9 to 14 Years and in Girls/Women Aged 15 to 20 Years in Zambia

This study is comparing the immune response generated by a single dose of the CERVAVAC HPV vaccine to that of the Gardasil vaccine in children and young adults aged 9 to 20 years. If the single-dose CERVAVAC vaccine proves to be just as effective, it could simplify vaccination schedules and improve access to HPV vaccination, especially in areas with limited healthcare resources. Results from this trial, which is recruiting in Zambia, will help determine if a single dose can provide strong protection against cervical cancer.

A Phase III Randomised Clinical Trial of Ultrasound Groin Monitoring Versus Groin Lymph Node Dissection to De-Escalate the Extent of Surgery in Vulvar Cancer

This trial is testing whether using ultrasound to monitor lymph nodes can safely replace more invasive surgery in patients with early-stage vulvar cancer. If ultrasound monitoring works, patients could avoid groin lymph node dissection surgery, which often comes with significant side effects and complications. The study is underway in Australia and aims to reduce the burden of surgery while maintaining effective cancer care.

Self-sampling for Non-attenders to Cervical Cancer Screening

This study explores whether allowing women who have not been attending regular cervical cancer screening to collect their own samples at home or in a clinic can increase screening rates. By making screening more convenient, this method could catch cervical changes earlier and reduce cancer rates among women who might otherwise avoid or delay testing. The trial is recruiting participants in Czechia and uses a simple self-sampling device for HPV testing.

Evidence-Based Approach to Empower Asian American Women in Cervical Cancer Screening

This completed study tested a community education program combined with providing self-sampling HPV kits to increase cervical cancer screening among Asian American women. The approach aims to make screening easier and more acceptable in a group that may face cultural or language barriers to traditional screening methods. Nearly 800 participants took part in this United States-based trial, and results are expected to inform ways to improve early detection in underserved communities.

Using Reiki Therapy to Improve Symptoms Associated With Brachytherapy in Patients With Gynecological Malignancies

This Phase 2 trial is investigating whether Reiki therapy can help reduce symptoms like anxiety and pain for patients receiving brachytherapy, a common treatment for gynecological cancers. If Reiki proves helpful, it could offer a gentle, non-drug option to improve the treatment experience for women undergoing radiation therapy. The study is recruiting patients in the United States who are starting their first brachytherapy session.

This week in women’s health and gynecology research, the focus remains on improving both prevention and treatment experiences. From potentially simplifying HPV vaccination to reducing surgery invasiveness and making cancer screening more accessible, the trials active now show a strong commitment to patient-centered care. Advances in supportive therapies like Reiki also highlight ongoing efforts to enhance quality of life during treatment. The coming months should bring important results that could shape future care options for women worldwide.

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