Digestive Health & Gastroenterology Clinical Trials Update: Week 23, 2026

Published June 5, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years

This study is testing tenapanor, a pill taken twice daily, as a treatment for irritable bowel syndrome with constipation (IBS-C) in children aged 12 to under 18. If tenapanor proves safe and effective, it could provide a new option to help young patients manage their symptoms more easily. The trial is currently active, with results expected after 12 weeks of treatment.

Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis

This Phase 3 trial is examining the use of oral tofacitinib to treat children with moderate to severe ulcerative colitis who have not responded well to other treatments. Covering ages 2 to 17, the study could offer a new way to control symptoms and inflammation in young patients. The trial is active but not recruiting, with treatment lasting up to 180 weeks.

Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples

This study is evaluating a new device called Cytosponge, which collects cells from the esophagus in a less invasive way than traditional endoscopy. It is aimed at detecting Barrett's esophagus and related conditions earlier and more comfortably. The trial is recruiting in the United States and plans to enroll 450 participants to see if this method can improve early diagnosis.

A Mobile Application to Improve the Quality of Colonoscopy in Colorectal Cancer Screening Program (PrepColon APP)

This trial tests a mobile app designed to help patients prepare better for colonoscopies during colorectal cancer screening. Improved preparation can lead to more accurate detection of colon issues and better prevention of cancer. The study is recruiting 470 participants in Spain and will assess if the app enhances colonoscopy quality by supporting diet and laxative use.

The Use of Butyrate Therapy in Pediatric Ulcerative Colitis

This Phase 2 study is exploring butyrate enemas as a treatment for children with ulcerative colitis, focusing on Hispanic pediatric patients in the United States. If effective, this therapy could offer a gentle option that targets gut health and reduces inflammation. The trial is currently recruiting participants.

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