Digestive Health & Gastroenterology Clinical Trials Update: Week 17, 2026

Published April 24, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

Psyllium in Pediatric IBS

This Phase 2 trial is exploring whether psyllium fiber supplements can help children with irritable bowel syndrome (IBS) who are sensitive to fructans, a type of carbohydrate. If the supplement reduces symptoms, it may provide a simple and natural way to improve digestive comfort and quality of life for these children. The study is currently recruiting participants in the United States and focuses on dietary changes combined with fiber intake.

COMPARE - Pediatric Inflammatory Bowel Disease (PIBD)

This study looks at newer medications for children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, who have not responded well to common anti-TNF treatments. By testing the safety and effectiveness of these newer drugs, the trial could offer additional options to better control symptoms and improve daily living for affected children. Recruitment is underway in the United States, with care managed by local healthcare providers.

Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial

This trial is testing less invasive methods to detect Barrett's esophagus and early esophageal cancer, including the use of artificial intelligence and a swallowable sponge test. These new diagnostic tools aim to make screening easier and less uncomfortable, which may lead to earlier detection and better treatment outcomes. The study is recruiting participants across the United States and plans to enroll about 1,010 people.

Influence of a Mediterranean Diet Combined With a Physical Activity Intervention, on NAFLD and Inflammation Parameters

Completed in Italy, this study examined how two versions of the Mediterranean diet combined with moderate aerobic exercise affect patients with non-alcoholic fatty liver disease (NAFLD), obesity, and IBS symptoms. The findings may help shape lifestyle advice by showing how diet and exercise together can reduce liver fat, lower inflammation, and improve digestive health. The trial involved 36 participants and suggests non-drug approaches could benefit people with these conditions.

Impact of GEA Simultaneous to VSG on Post-operative GERD

This ongoing trial in Brazil is investigating if combining gastroenteroanastomosis (GEA) surgery with vertical sleeve gastrectomy (VSG) can reduce symptoms of acid reflux after weight loss surgery in patients with obesity. The goal is to see if this combined surgical method improves reflux control and overall quality of life after surgery. The study is recruiting 60 participants and follows standard post-operative care routines.

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