Digestive Health & Gastroenterology Clinical Trials Update: Week 13, 2026

Published March 29, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )

This Phase 3 trial is testing lanifibranor, an oral medication, in adults with nonalcoholic steatohepatitis (NASH) and moderate to advanced liver fibrosis. For patients, this study represents hope for a new treatment that could improve liver health and reduce fibrosis, which is scarring of the liver that can lead to serious complications. The study involves over 1000 participants worldwide and is currently active but not recruiting.

Colorectal Cancer Screening in Cystic Fibrosis

This study is exploring stool-based DNA and FIT screening methods to detect colorectal cancer and precancerous growths in people with cystic fibrosis. These tests are less invasive than colonoscopy, which could make screening easier and more comfortable for patients. The trial is active and enrolling adults with cystic fibrosis at multiple centers in the United States.

A Study to Check the Safety of Dexlansoprazole and Learn If it Can Heal Erosive Esophagitis (EE) and Keep it Healed in Children 2 to 11 Years Old

This Phase 2 study is evaluating the safety and effectiveness of dexlansoprazole to treat erosive esophagitis in children aged 2 to 11 years. If successful, it may provide a new option to help heal this painful condition and maintain healing in young children. The trial is active but not recruiting, with sites in the United States, Canada, and other countries.

Randomized Study on Transoral Outlet Reduction and Lifestyle Changes for Weight Regain After Gastric Bypass

This study tests a procedure called Transoral Outlet Reduction (TORe) combined with lifestyle changes for adults who have regained weight after Roux-en-Y gastric bypass surgery. If this approach works, it could offer a way to help manage weight regain and improve long-term results after surgery. The trial is recruiting in the United States and will follow participants for two years.

Acupuncture for Colorectal sUrgery Recovery Enhancement: A Randomized Controlled Trial Evaluating Gastrointestinal Functional Recovery After Minimally Invasive Resection

This trial will test whether electroacupuncture can help patients recover bowel function faster after minimally invasive colorectal cancer surgery. Faster recovery could mean less discomfort and fewer postoperative complications. The study plans to enroll 240 patients but has not yet started recruiting.

The field of digestive health and gastroenterology continues to advance with studies focusing on improved treatments and less invasive screening options. From new medications to support liver and esophageal health, to innovations in weight management and surgical recovery, patients have promising options on the horizon. Ongoing research will help clarify how these approaches can best be used to improve digestive health and quality of life.

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