Diabetes & Endocrinology Clinical Trials Update: Week 33, 2026

Published August 14, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE)

This large study tested the oral medication RYBELSUS® against other blood sugar lowering pills for adults with type 2 diabetes who are already taking metformin. With over 1000 participants across the US, the results provide important information about how RYBELSUS® may offer a simpler way to control blood sugar levels. For patients, this could mean more treatment choices with a convenient daily pill that helps manage diabetes better.

This Study Is To Determine If Inhaled Insulin Is Effective In Treating Type 2 Diabetes Mellitus

This trial compared inhaled insulin to the usual insulin glargine injections for adults with type 2 diabetes not well controlled by oral medications. Conducted at many sites in the US and Puerto Rico, the study explored whether inhaled insulin could be a less invasive option. If proven effective, this might give patients a needle-free way to use insulin, which could improve comfort and ease of treatment.

A Research Study Comparing How Well Different Doses of the Medicine NN0519-0130 Lower Blood Sugar in People With Type 2 Diabetes

This Phase 2 study tested various doses of a new medicine called NNC0519-0130 to see how well it lowers blood sugar in adults with type 2 diabetes. Lasting about 40 weeks and involving participants from multiple countries, the study looked at weekly injections that might also help with weight control. For patients, this could mean a new option that manages blood sugar and body weight together, potentially improving overall diabetes care.

Efficacy and Safety of Berberine Ursodeoxycholate (HTD1801) in Patients With Type 2 Diabetes Inadequately Controlled With Metformin

This Phase 3 study is testing berberine ursodeoxycholate (HTD1801) in adults whose type 2 diabetes is not well controlled by metformin alone. Conducted in China with more than 500 participants, the trial aims to find a new treatment that can better manage blood sugar levels. If successful, this medication could provide additional help for patients struggling to keep their diabetes under control.

Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

This Phase 2 trial is investigating ABBV-295, an experimental injection, in adults who are obese or overweight and have related health problems. With about 360 participants in the US and Puerto Rico, the study is looking at whether this treatment can safely reduce weight and improve health outcomes over a year. For patients, this may offer a new option to support weight loss and reduce risks linked to excess weight.

TrialsAlert subscribers received the full impact-classified briefing and doctor-ready report this week. Get weekly briefings at trialsalert.com.