diabete Clinical Trials Update: Week 13, 2026

Published March 29, 2026 — 5 trials covered

By Victor Lafforgue, Founder of TrialsAlert. Blog posts are AI-drafted from ClinicalTrials.gov source data and reviewed by the editorial team. See our editorial policy for details.

Surgical or Medical Treatment

This Phase 4 study is comparing bariatric surgery with intensive medical therapy in children and youth who have type 2 diabetes. The goal is to find out if surgery can provide better long-term control of blood sugar and reduce complications more effectively than current medical treatments. This trial is recruiting in the United States and could offer important information for families considering surgery to manage diabetes in young people.

A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes

This Phase 3 trial is testing a new oral medication called orforglipron for adults who are overweight or living with obesity, including those with type 2 diabetes. If the drug works as hoped, it could become a convenient once-daily pill to help control weight and blood sugar levels. Results from this study may provide a new treatment option for managing both weight and diabetes.

A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)

This ongoing Phase 3 trial is investigating baricitinib, an oral medication, to see if it can help preserve insulin-producing cells in people recently diagnosed with type 1 diabetes. By maintaining these cells longer, the drug might improve blood sugar control and delay complications. The study includes both children and adults and is recruiting participants around the world.

Surveillance of Pancreatic Health After Diabetes Diagnosis

This study is testing a new blood test called Avantect to detect pancreatic cancer early in adults recently diagnosed with type 2 diabetes. Early detection of pancreatic cancer could lead to better treatment outcomes. The trial is recruiting in the United Kingdom and involves several visits over one year.

A Study of Investigational Tirzepatide (LY3298176) Doses in Participants With Type 2 Diabetes and Obesity

This Phase 2 study is evaluating different doses of tirzepatide, an experimental drug, in adults with type 2 diabetes and obesity who are already taking metformin. The goal is to see if tirzepatide can better control blood sugar and help reduce weight. Results are expected in the coming years, potentially adding another option for managing type 2 diabetes and obesity together.

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